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Grk1b and Grk7a Both Contribute to the Recovery of the Isolated Cone Photoresponse in Larval Zebrafish

PURPOSE: To define the functional roles of Grk1 and Grk7 in zebrafish cones in vivo. METHODS: Genome editing was used to generate grk7a and grk1b knockout zebrafish. Electroretinogram (ERG) analyses of the isolated cone mass receptor potential and the b-wave were performed in dark-adapted zebrafish...

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Detalles Bibliográficos
Autores principales: Chrispell, Jared D., Dong, Enheng, Osawa, Shoji, Liu, Jiandong, Cameron, D. Joshua, Weiss, Ellen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203174/
https://www.ncbi.nlm.nih.gov/pubmed/30372740
http://dx.doi.org/10.1167/iovs.18-24455