Vaccination by microneedle patch with inactivated respiratory syncytial virus and monophosphoryl lipid A enhances the protective efficacy and diminishes inflammatory disease after challenge

Intramuscular (IM) vaccination with formalin-inactivated respiratory syncytial virus (FI-RSV) failed in clinical trials due to vaccine-enhanced respiratory disease. To test the efficacy of skin vaccination against respiratory syncytial virus (RSV), we investigated the immunogenicity, efficacy, and i...

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Detalles Bibliográficos
Autores principales: Park, Soojin, Lee, Youri, Kwon, Young-Man, Lee, Young-Tae, Kim, Ki-Hye, Ko, Eun-Ju, Jung, Jae Hwan, Song, Manki, Graham, Barney, Prausnitz, Mark R., Kang, Sang-Moo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203256/
https://www.ncbi.nlm.nih.gov/pubmed/30365561
http://dx.doi.org/10.1371/journal.pone.0205071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203256/
https://www.ncbi.nlm.nih.gov/pubmed/30365561
http://dx.doi.org/10.1371/journal.pone.0205071

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