Cargando…

CD25 and TGF-β blockade based on predictive integrated immune ratio inhibits tumor growth in pancreatic cancer

BACKGROUND: The prognosis of pancreatic ductal adenocarcinoma (PDAC) remains poor due to the difficulty of disease diagnosis and therapy. Immunotherapy has had robust performance against several malignancies, including PDAC. In this study, we aim to analyze the expression of CD8 and FoxP3 on T lymph...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pu, Ning, Zhao, Guochao, Yin, Hanlin, Li, Jian-ang, Nuerxiati, Abulimiti, Wang, Dansong, Xu, Xuefeng, Kuang, Tiantao, Jin, Dayong, Lou, Wenhui, Wu, Wenchuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203282/ https://www.ncbi.nlm.nih.gov/pubmed/30359281 http://dx.doi.org/10.1186/s12967-018-1673-6

Ejemplares similares

Independent effect of postoperative neutrophil-to-lymphocyte ratio on the survival of pancreatic ductal adenocarcinoma with open distal pancreatosplenectomy and its nomogram-based prediction
por: Pu, Ning, et al.
Publicado: (2019)

Alkaline Phosphatase-To-Albumin Ratio as a Prognostic Indicator in Pancreatic Ductal Adenocarcinoma after Curative Resection
por: Pu, Ning, et al.
Publicado: (2017)

Gut-derived lipopolysaccharide remodels tumoral microenvironment and synergizes with PD-L1 checkpoint blockade via TLR4/MyD88/AKT/NF-κB pathway in pancreatic cancer
por: Yin, Hanlin, et al.
Publicado: (2021)

Comparison of prognostic prediction between nomogram based on lymph node ratio and AJCC 8th staging system for patients with resected pancreatic head carcinoma: a SEER analysis
por: Pu, Ning, et al.
Publicado: (2018)

GFAT1 is highly expressed in cancer stem cells of pancreatic cancer
por: Wang, Zhe, et al.
Publicado: (2022)

Neutralizing TGF-β promotes anti-tumor immunity of dendritic cells against pancreatic cancer by regulating T lymphocytes
por: Pu, Ning, et al.
Publicado: (2018)

Prognostic Effect of Age in Resected Pancreatic Cancer Patients: A Propensity Score Matching Analysis
por: Xu, Yaolin, et al.
Publicado: (2022)

Prognostic role of lymphocyte-to-monocyte ratio in pancreatic neuroendocrine neoplasms
por: Zhou, Wentao, et al.
Publicado: (2020)

PYCR1: A Potential Prognostic Biomarker in Pancreatic Ductal Adenocarcinoma
por: Wang, Huanyu, et al.
Publicado: (2022)

The Value of Alkaline Phosphatase-to-Albumin Ratio in Detecting Synchronous Metastases and Predicting Postoperative Relapses among Patients with Well-Differentiated Pancreatic Neuroendocrine Neoplasms
por: Zhou, Wentao, et al.
Publicado: (2020)

Prognostic value of histological subtype in intraductal papillary mucinous neoplasm of the pancreas: A retrospective analysis of outcome from one single center
por: Rong, Yefei, et al.
Publicado: (2017)

Circulating cytokines allow for identification of malignant intraductal papillary mucinous neoplasms of the pancreas
por: Pu, Ning, et al.
Publicado: (2022)

Laparoscopic versus open pancreaticoduodenectomy for pancreatic ductal adenocarcinoma: a propensity score matching analysis
por: Zhou, Wentao, et al.
Publicado: (2019)

Clinical relevance of different WHO grade 3 pancreatic neuroendocrine neoplasms based on morphology
por: Han, Xu, et al.
Publicado: (2018)

Granulocytic sarcoma of the pancreas: A case report and review of the literatures
por: Rong, Yefei, et al.
Publicado: (2010)

CD73 acts as a prognostic biomarker and promotes progression and immune escape in pancreatic cancer
por: Chen, Qiangda, et al.
Publicado: (2020)

Chemokine C‐C motif ligand 21 synergized with programmed death‐ligand 1 blockade restrains tumor growth
por: Chen, Qiangda, et al.
Publicado: (2021)

Prognostic value of tumor-associated N1/N2 neutrophil plasticity in patients following radical resection of pancreas ductal adenocarcinoma
por: Chen, Qiangda, et al.
Publicado: (2022)

Comprehensive Diagnostic Nomogram for Predicting Clinically Relevant Postoperative Pancreatic Fistula After Pancreatoduodenectomy
por: Li, Bo, et al.
Publicado: (2021)

Induction of protective and therapeutic anti-pancreatic cancer immunity using a reconstructed MUC1 DNA vaccine
por: Rong, Yefei, et al.
Publicado: (2009)

Should Steroid Therapy Be Necessarily Needed for Autoimmune Pancreatitis Patients with Lesion Resected due to Misdiagnosed or Suspected Malignancy?
por: Wu, Wenchuan, et al.
Publicado: (2014)

The value of systemic inflammatory markers in identifying malignancy in mucinous pancreatic cystic neoplasms
por: Zhou, Wentao, et al.
Publicado: (2017)

Proteomics analysis of serum protein profiling in pancreatic cancer patients by DIGE: up-regulation of mannose-binding lectin 2 and myosin light chain kinase 2
por: Rong, Yefei, et al.
Publicado: (2010)

Survival outcomes of pancreaticoduodenectomy versus extended pancreaticoduodenectomy procedure for pancreatic head carcinoma: a propensity score matching study
por: Pu, Ning, et al.
Publicado: (2020)

Clinicopathological Characteristics and Prognosis-Related Factors of Resectable Pancreatic Neuroendocrine Tumors: A Retrospective Study of 104 Cases in a Single Chinese Center
por: Han, Xu, et al.
Publicado: (2014)

Primary small cell carcinoma of the pancreas: rare type of pancreatic cancer and review of the literatures
por: Wang, Dansong, et al.
Publicado: (2012)

Clinical Analysis of Acinar Cell Carcinoma of the Pancreas: A Single-Center Experience of 45 Consecutive Cases
por: Zhou, Wentao, et al.
Publicado: (2020)

Current Role of Surgery in Pancreatic Cancer With Synchronous Liver Metastasis
por: Zhou, Wentao, et al.
Publicado: (2020)

HEATR1 Deficiency Promotes Chemoresistance via Upregulating ZNF185 and Downregulating SMAD4 in Pancreatic Cancer
por: Fang, Yuan, et al.
Publicado: (2020)

Tumor Microenvironment Responsive CD8(+) T Cells and Myeloid‐Derived Suppressor Cells to Trigger CD73 Inhibitor AB680‐Based Synergistic Therapy for Pancreatic Cancer
por: Chen, Qiangda, et al.
Publicado: (2023)

Tumor‐associated N1 and N2 neutrophils predict prognosis in patients with resected pancreatic ductal adenocarcinoma: A preliminary study
por: Yin, Hanlin, et al.
Publicado: (2022)

Additional adjuvant radiotherapy improves survival at 1 year after surgical treatment for pancreatic cancer patients with T(4), N(2) disease, positive resection margin, and receiving adjuvant chemotherapy
por: Wu, Lili, et al.
Publicado: (2023)

Combined test of serum CgA and NSE improved the power of prognosis prediction of NF-pNETs
por: Lv, Yang, et al.
Publicado: (2017)

Overexpression of miR-135b-5p promotes unfavorable clinical characteristics and poor prognosis via the repression of SFRP4 in pancreatic cancer
por: Han, Xu, et al.
Publicado: (2017)

Targeted deep sequencing reveals the genetic heterogeneity in well-differentiated pancreatic neuroendocrine tumors with liver metastasis
por: Zhou, Wentao, et al.
Publicado: (2022)

Basal microvilli define the metabolic capacity and lethal phenotype of pancreatic cancer
por: Han, Xu, et al.
Publicado: (2021)

Isolation, Structural Characterization, and Biological Activity of the Two Acidic Polysaccharides from the Fruits of the Elaeagnus angustifolia Linnaeus
por: Huojiaaihemaiti, Haibaier, et al.
Publicado: (2022)

DIAPH3 promotes pancreatic cancer progression by activating selenoprotein TrxR1‐mediated antioxidant effects
por: Rong, Yefei, et al.
Publicado: (2020)

Blockade of TGF-β signaling to enhance the antitumor response is accompanied by dysregulation of the functional activity of CD4(+)CD25(+)Foxp3(+) and CD4(+)CD25(−)Foxp3(+) T cells
por: Polanczyk, Magdalena J., et al.
Publicado: (2019)

Targeting TGFβR2‐mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancer
por: Huang, Huocong, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_0bb188hgsajvu73s9vr66rs2i4