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Involvement of VNUT-exocytosis in transient receptor potential vanilloid 4-dependent ATP release from gastrointestinal epithelium

Adenosine triphosphate (ATP) modulates mechanosensitive vagal afferent nerves in the gastrointestinal tract. ATP is stored in secretory vesicles via the ATP transporter VNUT. Recently, the bisphosphate clodronate was reported to inhibit VNUT and was suggested to be a safe potent therapeutic option f...

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Detalles Bibliográficos
Autores principales: Mihara, Hiroshi, Uchida, Kunitoshi, Koizumi, Schuichi, Moriyama, Yoshinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203352/
https://www.ncbi.nlm.nih.gov/pubmed/30365528
http://dx.doi.org/10.1371/journal.pone.0206276