Analgesic effects of a novel pH-dependent μ-opioid receptor agonist in models of neuropathic and abdominal pain

Recently, (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide (NFEPP), a newly designed μ-opioid receptor (MOR) agonist with a low pKa, has been shown to produce injury-restricted analgesia in models of inflammatory and postoperative pain, without exhibiting typical opioid side effects...

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Detalles Bibliográficos
Autores principales: Rodriguez-Gaztelumendi, Antonio, Spahn, Viola, Labuz, Dominika, Machelska, Halina, Stein, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203420/
https://www.ncbi.nlm.nih.gov/pubmed/29994988
http://dx.doi.org/10.1097/j.pain.0000000000001328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203420/
https://www.ncbi.nlm.nih.gov/pubmed/29994988
http://dx.doi.org/10.1097/j.pain.0000000000001328

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