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Analgesic effects of a novel pH-dependent μ-opioid receptor agonist in models of neuropathic and abdominal pain

Recently, (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenyl propionamide (NFEPP), a newly designed μ-opioid receptor (MOR) agonist with a low pKa, has been shown to produce injury-restricted analgesia in models of inflammatory and postoperative pain, without exhibiting typical opioid side effects...

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Detalles Bibliográficos
Autores principales:	Rodriguez-Gaztelumendi, Antonio, Spahn, Viola, Labuz, Dominika, Machelska, Halina, Stein, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203420/ https://www.ncbi.nlm.nih.gov/pubmed/29994988 http://dx.doi.org/10.1097/j.pain.0000000000001328

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