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DNA repair protein Rad18 restricts LINE-1 mobility

Long interspersed element-1 (LINE-1, L1) is a mobile genetic element comprising about 17% of the human genome. L1 utilizes an endonuclease to insert L1 cDNA into the target genomic DNA, which induces double-strand DNA breaks in the human genome and activates the DNA damage signaling pathway, resulti...

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Detalles Bibliográficos
Autores principales:	Ariumi, Yasuo, Kawano, Koudai, Yasuda-Inoue, Mariko, Kuroki, Misao, Fukuda, Hiroyuki, Siddiqui, Rokeya, Turelli, Priscilla, Tateishi, Satoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203705/ https://www.ncbi.nlm.nih.gov/pubmed/30367120 http://dx.doi.org/10.1038/s41598-018-34288-9

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