Single-Stranded Nucleic Acids Regulate TLR3/4/7 Activation through Interference with Clathrin-Mediated Endocytosis

Recognition of nucleic acids by endosomal Toll-like receptors (TLR) is essential to combat pathogens, but requires strict control to limit inflammatory responses. The mechanisms governing this tight regulation are unclear. We found that single-stranded oligonucleotides (ssON) inhibit endocytic pathw...

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Detalles Bibliográficos
Autores principales: Järver, Peter, Dondalska, Aleksandra, Poux, Candice, Sandberg, AnnSofi, Bergenstråhle, Joseph, Sköld, Annette E., Dereuddre-Bosquet, Nathalie, Martinon, Fréderic, Pålsson, Sandra, Zaghloul, Eman, Brodin, David, Sander, Birgitta, Lennox, Kim A., Behlke, Mark A., EL-Andaloussi, Samir, Lehtiö, Janne, Lundeberg, Joakim, LeGrand, Roger, Spetz, Anna-Lena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203749/
https://www.ncbi.nlm.nih.gov/pubmed/30367171
http://dx.doi.org/10.1038/s41598-018-33960-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203749/
https://www.ncbi.nlm.nih.gov/pubmed/30367171
http://dx.doi.org/10.1038/s41598-018-33960-4

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