IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates

Targeting the expansion of pathogenic memory immune cells is a promising therapeutic strategy to prevent chronic autoimmune attacks. Here we investigate the therapeutic efficacy and mechanism of new anti-human IL-7Rα monoclonal antibodies (mAb) in non-human primates and show that, depending on the t...

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Detalles Bibliográficos
Autores principales: Belarif, Lyssia, Mary, Caroline, Jacquemont, Lola, Mai, Hoa Le, Danger, Richard, Hervouet, Jeremy, Minault, David, Thepenier, Virginie, Nerrière-Daguin, Veronique, Nguyen, Elisabeth, Pengam, Sabrina, Largy, Eric, Delobel, Arnaud, Martinet, Bernard, Le Bas-Bernardet, Stéphanie, Brouard, Sophie, Soulillou, Jean-Paul, Degauque, Nicolas, Blancho, Gilles, Vanhove, Bernard, Poirier, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203796/
https://www.ncbi.nlm.nih.gov/pubmed/30367166
http://dx.doi.org/10.1038/s41467-018-06804-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203796/
https://www.ncbi.nlm.nih.gov/pubmed/30367166
http://dx.doi.org/10.1038/s41467-018-06804-y

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