Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance

Collagen prolyl 4-hydroxylase (P4H) expression and collagen hydroxylation in cancer cells are necessary for breast cancer progression. Here, we show that P4H alpha 1 subunit (P4HA1) protein expression is induced in triple-negative breast cancer (TNBC) and HER2 positive breast cancer. By modulating a...

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Detalles Bibliográficos
Autores principales: Xiong, Gaofeng, Stewart, Rachel L., Chen, Jie, Gao, Tianyan, Scott, Timothy L., Samayoa, Luis M., O’Connor, Kathleen, Lane, Andrew N., Xu, Ren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203834/
https://www.ncbi.nlm.nih.gov/pubmed/30367042
http://dx.doi.org/10.1038/s41467-018-06893-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203834/
https://www.ncbi.nlm.nih.gov/pubmed/30367042
http://dx.doi.org/10.1038/s41467-018-06893-9

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