ASXL1 and SETBP1 mutations promote leukaemogenesis by repressing TGFβ pathway genes through histone deacetylation

Mutations in ASXL1 and SETBP1 genes have been frequently detected and often coexist in myelodysplastic syndrome (MDS) and acute myeloid leukaemia (AML). We previously showed that coexpression of mutant ASXL1 and SETBP1 in hematopoietic progenitor cells induced downregulation of TGFβ pathway genes an...

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Detalles Bibliográficos
Autores principales: Saika, Makoto, Inoue, Daichi, Nagase, Reina, Sato, Naru, Tsuchiya, Akiho, Yabushita, Tomohiro, Kitamura, Toshio, Goyama, Susumu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203835/
https://www.ncbi.nlm.nih.gov/pubmed/30367089
http://dx.doi.org/10.1038/s41598-018-33881-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203835/
https://www.ncbi.nlm.nih.gov/pubmed/30367089
http://dx.doi.org/10.1038/s41598-018-33881-2

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