Cell cycle inhibitors protect motor neurons in an organoid model of Spinal Muscular Atrophy

Spinal Muscular Atrophy (SMA) is caused by genetic mutations in the SMN1 gene, resulting in drastically reduced levels of Survival of Motor Neuron (SMN) protein. Although SMN is ubiquitously expressed, spinal motor neurons are one of the most affected cell types. Previous studies have identified pat...

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Detalles Bibliográficos
Autores principales: Hor, Jin Hui, Soh, Eunice Shi-Yi, Tan, Li Yi, Lim, Valerie Jing Wen, Santosa, Munirah Mohamad, Winanto, Ho, Beatrice Xuan, Fan, Yong, Soh, Boon-Seng, Ng, Shi-Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204135/
https://www.ncbi.nlm.nih.gov/pubmed/30368521
http://dx.doi.org/10.1038/s41419-018-1081-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204135/
https://www.ncbi.nlm.nih.gov/pubmed/30368521
http://dx.doi.org/10.1038/s41419-018-1081-0

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