Cargando…

Cell cycle inhibitors protect motor neurons in an organoid model of Spinal Muscular Atrophy

Spinal Muscular Atrophy (SMA) is caused by genetic mutations in the SMN1 gene, resulting in drastically reduced levels of Survival of Motor Neuron (SMN) protein. Although SMN is ubiquitously expressed, spinal motor neurons are one of the most affected cell types. Previous studies have identified pat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hor, Jin Hui, Soh, Eunice Shi-Yi, Tan, Li Yi, Lim, Valerie Jing Wen, Santosa, Munirah Mohamad, Winanto, Ho, Beatrice Xuan, Fan, Yong, Soh, Boon-Seng, Ng, Shi-Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204135/ https://www.ncbi.nlm.nih.gov/pubmed/30368521 http://dx.doi.org/10.1038/s41419-018-1081-0

Ejemplares similares

Organoid cultures of MELAS neural cells reveal hyperactive Notch signaling that impacts neurodevelopment
por: Winanto, et al.
Publicado: (2020)

ALS motor neurons exhibit hallmark metabolic defects that are rescued by SIRT3 activation
por: Hor, Jin-Hui, et al.
Publicado: (2020)

Spinal cord organoids add an extra dimension to traditional motor neuron cultures
por: Winanto,, et al.
Publicado: (2019)

Disease Modeling Using 3D Organoids Derived from Human Induced Pluripotent Stem Cells
por: Ho, Beatrice Xuan, et al.
Publicado: (2018)

Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids
por: Pang, Jeremy Kah Sheng, et al.
Publicado: (2021)

Microhexagon gradient array directs spatial diversification of spinal motor neurons
por: Lim, Geok Soon, et al.
Publicado: (2019)

Wnt/β-catenin-mediated signaling re-activates proliferation of matured cardiomyocytes
por: Fan, Yong, et al.
Publicado: (2018)

Robust generation of human-chambered cardiac organoids from pluripotent stem cells for improved modelling of cardiovascular diseases
por: Ho, Beatrice Xuan, et al.
Publicado: (2022)

Mending a broken heart: current strategies and limitations of cell-based therapy
por: Liew, Lee Chuen, et al.
Publicado: (2020)

3D Human Organoids: The Next “Viral” Model for the Molecular Basis of Infectious Diseases
por: Chia, Shirley Pei Shan, et al.
Publicado: (2022)

Motor unit changes in children with symptomatic spinal muscular atrophy treated with nusinersen
por: Kariyawasam, Didu, et al.
Publicado: (2021)

Remodeling of astrocyte secretome in amyotrophic lateral sclerosis: uncovering novel targets to combat astrocyte-mediated toxicity
por: Ng, Winanto, et al.
Publicado: (2022)

Characterizing arrhythmia using machine learning analysis of Ca(2+) cycling in human cardiomyocytes
por: Pang, Jeremy K.S., et al.
Publicado: (2022)

Increasing Agrin Function Antagonizes Muscle Atrophy and Motor Impairment in Spinal Muscular Atrophy
por: Boido, Marina, et al.
Publicado: (2018)

Mitochondrial 3243A > G mutation confers pro-atherogenic and pro-inflammatory properties in MELAS iPS derived endothelial cells
por: Pek, Nicole Min Qian, et al.
Publicado: (2019)

In Vivo Genome Editing as a Therapeutic Approach
por: Ho, Beatrice Xuan, et al.
Publicado: (2018)

Spinal muscular atrophy patient-derived motor neurons exhibit hyperexcitability
por: Liu, Huisheng, et al.
Publicado: (2015)

Inherited Paediatric Motor Neuron Disorders: Beyond Spinal Muscular Atrophy
por: Teoh, Hooi Ling, et al.
Publicado: (2017)

Replacing what’s lost: a new era of stem cell therapy for Parkinson’s disease
por: Fan, Yong, et al.
Publicado: (2020)

Systematic Literature Review of the Natural History of Spinal Muscular Atrophy: Motor Function, Scoliosis, and Contractures
por: Aponte Ribero, Valerie, et al.
Publicado: (2023)

Mechanisms of exercise‐induced survival motor neuron expression in the skeletal muscle of spinal muscular atrophy‐like mice
por: Ng, Sean Y., et al.
Publicado: (2019)

Spinal muscular atrophy
por: D'Amico, Adele, et al.
Publicado: (2011)

Progressive Muscular Atrophy
por: Omar, A.
Publicado: (1947)

Progressive Muscular Atrophy
por: Omar, A.
Publicado: (1947)

Progressive Muscular Atrophy
por: Omer, M. A.
Publicado: (1949)

Muscular Atrophy and Sclerodermia
por: Nixon, J. A.
Publicado: (1903)

Progressive Muscular Atrophy
Publicado: (1874)

Muscular Atrophy and Sclerodermia
Publicado: (1904)

Acute Muscular Atrophy
por: Haddon, John
Publicado: (1870)

Case of Muscular Atrophy
por: Kersey, V.
Publicado: (1871)

Different trajectories in upper limb and gross motor function in spinal muscular atrophy
por: Coratti, Giorgia, et al.
Publicado: (2021)

Case of Marked Muscular Atrophy of Hands and Fore-Arms—Progressive Muscular Atrophy(?)
por: Ness, R. Barclay
Publicado: (1895)

Upregulation of the JAK-STAT pathway promotes maturation of human embryonic stem cell-derived cardiomyocytes
por: Ho, Beatrice Xuan, et al.
Publicado: (2021)

Fibrosis, Adipogenesis, and Muscle Atrophy in Congenital Muscular Torticollis
por: Chen, Huan-xiong, et al.
Publicado: (2014)

Whole blood survival motor neuron protein levels correlate with severity of denervation in spinal muscular atrophy
por: Alves, Christiano R. R., et al.
Publicado: (2020)

Utility of Survival Motor Neuron ELISA for Spinal Muscular Atrophy Clinical and Preclinical Analyses
por: Kobayashi, Dione T., et al.
Publicado: (2011)

CSF cytokine profile distinguishes multifocal motor neuropathy from progressive muscular atrophy
por: Furukawa, Takahiro, et al.
Publicado: (2015)

Modeling the phenotype of spinal muscular atrophy by the direct conversion of human fibroblasts to motor neurons
por: Zhang, Qi-Jie, et al.
Publicado: (2017)

Spinal Muscular Atrophy: The Use of Functional Motor Scales in the Era of Disease-Modifying Treatment
por: Pierzchlewicz, Katarzyna, et al.
Publicado: (2021)

Motor unit recovery following Smn restoration in mouse models of spinal muscular atrophy
por: Comley, Laura H, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_mu2redp4k5sicbh4tolddnj5nu