Structures of filaments from Pick’s disease reveal a novel tau protein fold

The ordered assembly of tau protein into abnormal filamentous inclusions underlies many human neurodegenerative diseases(1). Tau assemblies appear to spread through specific neural networks in each disease(2), with short filaments having the greatest seeding activity(3). The abundance of tau inclusi...

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Detalles Bibliográficos
Autores principales: Falcon, Benjamin, Zhang, Wenjuan, Murzin, Alexey G., Murshudov, Garib, Garringer, Holly J., Vidal, Ruben, Crowther, R. Anthony, Ghetti, Bernardino, Scheres, Sjors H.W., Goedert, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204212/
https://www.ncbi.nlm.nih.gov/pubmed/30158706
http://dx.doi.org/10.1038/s41586-018-0454-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204212/
https://www.ncbi.nlm.nih.gov/pubmed/30158706
http://dx.doi.org/10.1038/s41586-018-0454-y

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