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Delivery of shRNA via lentivirus in human pseudoislets provides a model to test dynamic regulation of insulin secretion and gene function in human islets

Rodent islets are widely used to study the pathophysiology of beta cells and islet function, however, structural and functional differences exist between human and rodent islets, highlighting the need for human islet studies. Human islets are highly variable, deteriorate during culture, and are diff...

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Detalles Bibliográficos
Autores principales: Harata, Mikako, Liu, Siming, Promes, Joseph A., Burand, Anthony J., Ankrum, James A., Imai, Yumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204361/
https://www.ncbi.nlm.nih.gov/pubmed/30370689
http://dx.doi.org/10.14814/phy2.13907