PEGylated Domain I of Beta-2-Glycoprotein I Inhibits the Binding, Coagulopathic, and Thrombogenic Properties of IgG From Patients With the Antiphospholipid Syndrome

APS is an autoimmune disease in which antiphospholipid antibodies (aPL) cause vascular thrombosis and pregnancy morbidity. In patients with APS, aPL exert pathogenic actions by binding serum beta-2-glycoprotein I (β2GPI) via its N-terminal domain I (DI). We previously showed that bacterially-express...

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Detalles Bibliográficos
Autores principales: McDonnell, Thomas C. R., Willis, Rohan, Pericleous, Charis, Ripoll, Vera M., Giles, Ian P., Isenberg, David. A., Brasier, Allan R., Gonzalez, Emilio B., Papalardo, Elizabeth, Romay-Penabad, Zurina, Jamaluddin, Mohammad, Ioannou, Yiannis, Rahman, Anisur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204385/
https://www.ncbi.nlm.nih.gov/pubmed/30405613
http://dx.doi.org/10.3389/fimmu.2018.02413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204385/
https://www.ncbi.nlm.nih.gov/pubmed/30405613
http://dx.doi.org/10.3389/fimmu.2018.02413

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