Extending human IgG half-life using structure-guided design

Engineering of antibodies for improved pharmacokinetics through enhanced binding to the neonatal Fc receptor (FcRn) has been demonstrated in transgenic mice, non-human primates and humans. Traditionally, such approaches have largely relied on random mutagenesis and display formats, which fail to add...

Descripción completa

Detalles Bibliográficos
Autores principales: Booth, Brian J., Ramakrishnan, Boopathy, Narayan, Kristin, Wollacott, Andrew M., Babcock, Gregory J., Shriver, Zachary, Viswanathan, Karthik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204840/
https://www.ncbi.nlm.nih.gov/pubmed/29947573
http://dx.doi.org/10.1080/19420862.2018.1490119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204840/
https://www.ncbi.nlm.nih.gov/pubmed/29947573
http://dx.doi.org/10.1080/19420862.2018.1490119

Ejemplares similares