Oligogenic genetic variation of neurodegenerative disease genes in 980 postmortem human brains

BACKGROUND: Several studies suggest that multiple rare genetic variants in genes causing monogenic forms of neurodegenerative disorders interact synergistically to increase disease risk or reduce the age of onset, but these studies have not been validated in large sporadic case series. METHODS: We a...

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Detalles Bibliográficos
Autores principales: Keogh, Michael J, Wei, Wei, Aryaman, Juvid, Wilson, Ian, Talbot, Kevin, Turner, Martin R, McKenzie, Chris-Anne, Troakes, Claire, Attems, Johannes, Smith, Colin, Al Sarraj, Safa, Morris, Chris M, Ansorge, Olaf, Pickering-Brown, Stuart, Jones, Nick, Ironside, James W, Chinnery, Patrick F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Neurodegeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204946/
https://www.ncbi.nlm.nih.gov/pubmed/29332010
http://dx.doi.org/10.1136/jnnp-2017-317234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204946/
https://www.ncbi.nlm.nih.gov/pubmed/29332010
http://dx.doi.org/10.1136/jnnp-2017-317234

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