Enhanced gut barrier integrity sensitizes colon cancer to immune therapy

Oral IL-10 suppressed tumor growth in the APC(min/+) mouse/Bacteroides fragilis colon cancer model while a similar formulation of IL-12 exacerbated disease. In contrast, combined treatment with IL-10 and IL-12 resulted in near-complete tumor eradication and a significant extension of survival. The c...

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Detalles Bibliográficos
Autores principales: Bhutiani, Neal, Li, Qingsheng, Anderson, Charles D., Gallagher, Heather C., De Jesus, Magdia, Singh, Rajbir, Jala, Venkatkrishna R., Fraig, Mostafa, Gu, Tao, Egilmez, Nejat K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204984/
https://www.ncbi.nlm.nih.gov/pubmed/30377564
http://dx.doi.org/10.1080/2162402X.2018.1498438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204984/
https://www.ncbi.nlm.nih.gov/pubmed/30377564
http://dx.doi.org/10.1080/2162402X.2018.1498438

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