Adeno-Associated Virus Neutralizing Antibodies in Large Animals and Their Impact on Brain Intraparenchymal Gene Transfer

Pre-existing neutralizing antibody (NAb) against adeno-associated virus (AAV) commonly found in primates is a major host barrier that can severely compromise in vivo gene transfer by AAV vectors. To achieve proof-of-concept success in clinical development of recombinant AAV (rAAV)-based in vivo gene...

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Detalles Bibliográficos
Autores principales: Wang, Dan, Zhong, Li, Li, Mengxin, Li, Jia, Tran, Karen, Ren, Lingzhi, He, Ran, Xie, Jun, Moser, Richard P., Fraser, Cara, Kuchel, Tim, Sena-Esteves, Miguel, Flotte, Terence R., Aronin, Neil, Gao, Guangping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205343/
https://www.ncbi.nlm.nih.gov/pubmed/30397628
http://dx.doi.org/10.1016/j.omtm.2018.09.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205343/
https://www.ncbi.nlm.nih.gov/pubmed/30397628
http://dx.doi.org/10.1016/j.omtm.2018.09.003

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