Dihomo-γ-linolenic acid inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA

We recently reported that siRNA-knockdown of delta-5-desaturase (D5D), the rate-limiting enzyme converting upstream ω − 6 dihomo-γ-linolenic acid (DGLA) to arachidonic acid, promoted formation of the anti-cancer byproduct 8-hydroxyoctanoic acid (8-HOA) from COX-2-catalyzed DGLA peroxidation, consequ...

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Detalles Bibliográficos
Autores principales: Yang, Xiaoyu, Xu, Yi, Gao, Di, Yang, Liu, Qian, Steven Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205412/
https://www.ncbi.nlm.nih.gov/pubmed/30384258
http://dx.doi.org/10.1016/j.redox.2018.10.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205412/
https://www.ncbi.nlm.nih.gov/pubmed/30384258
http://dx.doi.org/10.1016/j.redox.2018.10.001

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