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Entropic contribution to enhanced thermal stability in the thermostable P450 CYP119

The enhanced thermostability of thermophilic proteins with respect to their mesophilic counterparts is often attributed to the enthalpy effect, arising from strong interactions between protein residues. Intuitively, these strong interresidue interactions will rigidify the biomolecules. However, the...

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Detalles Bibliográficos
Autores principales: Liu, Zhuo, Lemmonds, Sara, Huang, Juan, Tyagi, Madhusudan, Hong, Liang, Jain, Nitin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205451/
https://www.ncbi.nlm.nih.gov/pubmed/30297413
http://dx.doi.org/10.1073/pnas.1807473115