IDH1(R132H) is intrinsically tumor-suppressive but functionally attenuated by the glutamate-rich cerebral environment

Recurrent heterozygous mutation of isocitrate dehydrogenase 1 gene (IDH1), predominantly resulting in histidine substitution at arginine 132, was first identified in glioma. The biological significance of IDH1(R132H), however, has been controversial, and its prevalent association with glioma remains...

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Detalles Bibliográficos
Autores principales: Tiburcio, Patricia D.B., Xiao, Bing, Chai, Yi, Asper, Sydney, Tripp, Sheryl R., Gillespie, David L., Jensen, Randy L., Huang, L. Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205547/
https://www.ncbi.nlm.nih.gov/pubmed/30416682
http://dx.doi.org/10.18632/oncotarget.26203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205547/
https://www.ncbi.nlm.nih.gov/pubmed/30416682
http://dx.doi.org/10.18632/oncotarget.26203

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