Cargando…
Identification of Amino Acids Essential for Viral Replication in the HCMV Helicase-Primase Complex
Promising new inhibitors that target the viral helicase-primase complex have been reported to block replication of herpes simplex and varicella-zoster viruses, but they have no activity against human cytomegalovirus (HCMV), another herpesvirus. The HCMV helicase-primase complex (pUL105-pUL102-pUL70)...
Autores principales: | Ligat, Gaetan, Da Re, Sandra, Alain, Sophie, Hantz, Sébastien |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205958/ https://www.ncbi.nlm.nih.gov/pubmed/30405556 http://dx.doi.org/10.3389/fmicb.2018.02483 |
Ejemplares similares
-
Towards a Prophylactic Vaccine for the Prevention of HCMV Infection
por: Ligat, Gaëtan, et al.
Publicado: (2021) -
Highlighting of a LAGLIDADG and a Zing Finger Motifs Located in the pUL56 Sequence Crucial for HCMV Replication
por: Ligat, Gaëtan, et al.
Publicado: (2019) -
Identification of a short sequence in the HCMV terminase pUL56 essential for interaction with pUL89 subunit
por: Ligat, G., et al.
Publicado: (2017) -
Residues located in the primase domain of the bacteriophage T7 primase-helicase are essential for loading the hexameric complex onto DNA
por: Hernandez, Alfredo J., et al.
Publicado: (2022) -
Primase is required for helicase activity and helicase alters the specificity of primase in the enteropathogen Clostridium difficile
por: van Eijk, Erika, et al.
Publicado: (2016)