6mer seed toxicity in tumor suppressive microRNAs

Many small-interfering (si)RNAs are toxic to cancer cells through a 6mer seed sequence (positions 2–7 of the guide strand). Here we performed an siRNA screen with all 4096 6mer seeds revealing a preference for guanine in positions 1 and 2 and a high overall G or C content in the seed of the most tox...

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Detalles Bibliográficos
Autores principales: Gao, Quan Q., Putzbach, William E., Murmann, Andrea E., Chen, Siquan, Sarshad, Aishe A., Peter, Johannes M., Bartom, Elizabeth T., Hafner, Markus, Peter, Marcus E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206098/
https://www.ncbi.nlm.nih.gov/pubmed/30374110
http://dx.doi.org/10.1038/s41467-018-06526-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206098/
https://www.ncbi.nlm.nih.gov/pubmed/30374110
http://dx.doi.org/10.1038/s41467-018-06526-1

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