An unusually high substitution rate in transplant-associated BK polyomavirus in vivo is further concentrated in HLA-C-bound viral peptides

Infection with human BK polyomavirus, a small double-stranded DNA virus, potentially results in severe complications in immunocompromised patients. Here, we describe the in vivo variability and evolution of the BK polyomavirus by deep sequencing. Our data reveal the highest genomic evolutionary rate...

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Detalles Bibliográficos
Autores principales: Domingo-Calap, Pilar, Schubert, Benjamin, Joly, Mélanie, Solis, Morgane, Untrau, Meiggie, Carapito, Raphael, Georgel, Philippe, Caillard, Sophie, Fafi-Kremer, Samira, Paul, Nicodème, Kohlbacher, Oliver, González-Candelas, Fernando, Bahram, Seiamak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207329/
https://www.ncbi.nlm.nih.gov/pubmed/30335851
http://dx.doi.org/10.1371/journal.ppat.1007368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207329/
https://www.ncbi.nlm.nih.gov/pubmed/30335851
http://dx.doi.org/10.1371/journal.ppat.1007368

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