Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase

Metformin is a first-line drug for the treatment of individuals with type 2 diabetes, yet its precise mechanism of action remains unclear. Metformin exerts its anti-hyperglycemic action primarily through lowering of hepatic glucose production (HGP). This suppression is thought to be mediated through...

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Bibliographic Details
Main Authors: Hunter, Roger W., Hughey, Curtis C., Lantier, Louise, Sundelin, Elias I., Peggie, Mark, Zeqiraj, Elton, Sicheri, Frank, Jessen, Niels, Wasserman, David H., Sakamoto, Kei
Format: Online Article Text
Language:English
Published: 2018
Subjects:
Article
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207338/
https://www.ncbi.nlm.nih.gov/pubmed/30150719
http://dx.doi.org/10.1038/s41591-018-0159-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207338/
https://www.ncbi.nlm.nih.gov/pubmed/30150719
http://dx.doi.org/10.1038/s41591-018-0159-7

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