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Clusterin is highly expressed in tubular complexes during spontaneous pancreatitis of spontaneous hypertensive rats

Pancreatitis is an inflammatory disorder of pancreas which leads to varying degrees of pancreatic endocrine and exocrine dysfunction and manifests in either acute or chronic forms. Spontaneous pancreatitis in experimental animals has rarely been reported. Here, we found acute to chronic courses of s...

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Detalles Bibliográficos
Autores principales: PARK, Jun Won, NAM, Ki Taek, SHIN, Jae Hoon, KIM, Il Yong, CHOI, Kyung Mi, ROH, Kyung-Jin, OH, Seung Hyun, YUN, Young-Min, SUH, Jun-Gyo, OH, Yang-Seok, YOON, Yeo Sung, SEONG, Je Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207517/
https://www.ncbi.nlm.nih.gov/pubmed/30111670
http://dx.doi.org/10.1292/jvms.18-0205
Descripción
Sumario:Pancreatitis is an inflammatory disorder of pancreas which leads to varying degrees of pancreatic endocrine and exocrine dysfunction and manifests in either acute or chronic forms. Spontaneous pancreatitis in experimental animals has rarely been reported. Here, we found acute to chronic courses of spontaneous pancreatitis in spontaneously hypertensive rats (SHRs), showing the formation of tubular complexes (TCs) and enhanced islet regeneration. We investigated the expression pattern of clusterin in the pancreas of SHRs based on immunohistochemistry (IHC). IHC analysis revealed the strong expression of clusterin in dedifferentiated duct-like cells and regenerative islets of TCs. These results imply that clusterin might be involved in the formation of TCs and parenchymal regeneration during rat pancreatitis.