Identification and antitumor activity of a novel inhibitor of the NIMA-related kinase NEK6

The NIMA (never in mitosis, gene A)-related kinase-6 (NEK6), which is implicated in cell cycle control and plays significant roles in tumorigenesis, is an attractive target for the development of novel anti-cancer drugs. Here we describe the discovery of a potent ATP site-directed inhibitor of NEK6...

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Detalles Bibliográficos
Autores principales: De Donato, Marta, Righino, Benedetta, Filippetti, Flavia, Battaglia, Alessandra, Petrillo, Marco, Pirolli, Davide, Scambia, Giovanni, De Rosa, Maria Cristina, Gallo, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207720/
https://www.ncbi.nlm.nih.gov/pubmed/30375481
http://dx.doi.org/10.1038/s41598-018-34471-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207720/
https://www.ncbi.nlm.nih.gov/pubmed/30375481
http://dx.doi.org/10.1038/s41598-018-34471-y

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