Mechanism of activating mutations and allosteric drug inhibition of the phosphatase SHP2

Protein tyrosine phosphatase SHP2 functions as a key regulator of cell cycle control, and activating mutations cause several cancers. Here, we dissect the energy landscape of wild-type SHP2 and the oncogenic mutation E76K. NMR spectroscopy and X-ray crystallography reveal that wild-type SHP2 exchang...

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Detalles Bibliográficos
Autores principales: Pádua, Ricardo A. P., Sun, Yizhi, Marko, Ingrid, Pitsawong, Warintra, Stiller, John B., Otten, Renee, Kern, Dorothee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207724/
https://www.ncbi.nlm.nih.gov/pubmed/30375376
http://dx.doi.org/10.1038/s41467-018-06814-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207724/
https://www.ncbi.nlm.nih.gov/pubmed/30375376
http://dx.doi.org/10.1038/s41467-018-06814-w

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