Editing the duplicated insulin-like growth factor binding protein-2b gene in rainbow trout (Oncorhynchus mykiss)

In salmonids, the majority of circulating insulin-like growth factor-I (IGF-I) is bound to IGF binding proteins (IGFBP), with IGFBP-2b being the most abundant in circulation. We used CRISPR/Cas9 methodology to disrupt expression of a functional IGFBP-2b protein by co-targeting for gene editing IGFBP...

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Detalles Bibliográficos
Autores principales: Cleveland, Beth M., Yamaguchi, Ginnosuke, Radler, Lisa M., Shimizu, Munetaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207780/
https://www.ncbi.nlm.nih.gov/pubmed/30375441
http://dx.doi.org/10.1038/s41598-018-34326-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207780/
https://www.ncbi.nlm.nih.gov/pubmed/30375441
http://dx.doi.org/10.1038/s41598-018-34326-6

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