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Structure-based assessment and network analysis of targeting 14-3-3 proteins in prostate cancer

Developing combination therapy for castrate-resistant prostate cancer (CRPC) may require exploiting new drug targets outside androgen receptor and PI3K / AKT / mTOR signal transduction pathways implicated in prostate cancer (PCa) progression. One such possible new target is YWHAZ of the 14-3-3 prote...

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Detalles Bibliográficos
Autores principales: Root, Alex, Beizaei, Azadeh, Ebhardt, H. Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208026/
https://www.ncbi.nlm.nih.gov/pubmed/30382885
http://dx.doi.org/10.1186/s12943-018-0905-y