Src-family kinase-Cbl axis negatively regulates NLRP3 inflammasome activation

Activation of the NLRP3 inflammasome is crucial for immune defense, but improper and excessive activation causes inflammatory diseases. We previously reported that Pyk2 is essential for NLRP3 inflammasome activation. Here we show that the Src-family kinases (SFKs)-Cbl axis plays a pivotal role in su...

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Detalles Bibliográficos
Autores principales: Chung, I-Che, Yuan, Sheng-Ning, OuYang, Chun-Nan, Lin, Hsin-Chung, Huang, Kuo-Yang, Chen, Yu-Jen, Chung, An-Ko, Chu, Ching-Liang, Ojcius, David M., Chang, Yu-Sun, Chen, Lih-Chyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208430/
https://www.ncbi.nlm.nih.gov/pubmed/30382081
http://dx.doi.org/10.1038/s41419-018-1163-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208430/
https://www.ncbi.nlm.nih.gov/pubmed/30382081
http://dx.doi.org/10.1038/s41419-018-1163-z

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