The PDL1-inducible GTPase Arl4d controls T effector function by limiting IL-2 production

Interleukin-2 (IL-2) is a key regulator of adaptive immune responses but its regulation is incompletely understood. We previously found that PDL1-dependent signals were pivotal for liver sinusoidal endothelial cell-mediated priming of CD8 T cells, which have a strongly reduced capacity to produce IL...

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Detalles Bibliográficos
Autores principales: Tolksdorf, Felix, Mikulec, Julita, Geers, Bernd, Endig, Jessica, Sprezyna, Paulina, Heukamp, Lukas C., Knolle, Percy A., Kolanus, Waldemar, Diehl, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208435/
https://www.ncbi.nlm.nih.gov/pubmed/30382149
http://dx.doi.org/10.1038/s41598-018-34522-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208435/
https://www.ncbi.nlm.nih.gov/pubmed/30382149
http://dx.doi.org/10.1038/s41598-018-34522-4

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