Epitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau

In Alzheimer’s disease (AD) and other tauopathies, the cytosolic protein Tau misfolds and forms intracellular aggregates which accumulate within the brain leading to neurodegeneration. Clinical progression is tightly linked to the progressive spread of Tau pathology throughout the brain, and several...

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Detalles Bibliográficos
Autores principales: Courade, Jean-Philippe, Angers, Rachel, Mairet-Coello, Georges, Pacico, Nathalie, Tyson, Kerry, Lightwood, Daniel, Munro, Rebecca, McMillan, David, Griffin, Robert, Baker, Terry, Starkie, Dale, Nan, Ruodan, Westwood, Marta, Mushikiwabo, Marie-Laetitia, Jung, Sophie, Odede, Geofrey, Sweeney, Berni, Popplewell, Andrew, Burgess, Gillian, Downey, Patrick, Citron, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208734/
https://www.ncbi.nlm.nih.gov/pubmed/30238240
http://dx.doi.org/10.1007/s00401-018-1911-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208734/
https://www.ncbi.nlm.nih.gov/pubmed/30238240
http://dx.doi.org/10.1007/s00401-018-1911-2

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