Genetic polymorphisms of 3′-untranslated region of SULT1A1 and their impact on tamoxifen metabolism and efficacy

PURPOSE: Tamoxifen has a wide inter-variability. Recently, two SNPs in the 3′-untranslated region (UTR) of the SULT1A1 gene, rs6839 and rs1042157, have been associated with decreased SULT1A1 activity. The aim of this study is to investigate the role of the rs6839 and rs1042157 on tamoxifen metabolis...

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Detalles Bibliográficos
Autores principales: Sanchez-Spitman, A. B., Dezentjé, V. O., Swen, J. J., Moes, D. J. A. R., Gelderblom, H., Guchelaar, Henk-Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Clinical Trial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208901/
https://www.ncbi.nlm.nih.gov/pubmed/30120701
http://dx.doi.org/10.1007/s10549-018-4923-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208901/
https://www.ncbi.nlm.nih.gov/pubmed/30120701
http://dx.doi.org/10.1007/s10549-018-4923-7

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