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Riluzole induces LTD of spinal nociceptive signaling via postsynaptic GluR2 receptors

PURPOSE: Riluzole – a major therapeutic medicine for patients with amyotrophic lateral sclerosis – reportedly has anti-nociceptive and anti-allodynic efficacies in neuropathic pain models. However, little is known about its effect on neurotransmission in the spinal superficial dorsal horn (SDH). The...

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Detalles Bibliográficos
Autores principales: Zhang, Xiao, Gao, Yandong, Wang, Qun, Du, Shibin, He, Xiaolan, Gu, Nan, Lu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209077/
https://www.ncbi.nlm.nih.gov/pubmed/30464577
http://dx.doi.org/10.2147/JPR.S169686