Under expression of the Sonic Hedgehog receptor, Patched1 (PTCH1), is associated with an increased risk of local recurrence in squamous cell carcinoma of the vulva arising on a background of Lichen Sclerosus

OBJECTIVE: Dysregulation of the Hedgehog (Hh) pathway has been described in a variety of cancers, including cervical cancer, a disease which shares a common aetiology with vulval squamous cell carcinoma (VSCC). Here, we investigate a large number of primary VSCC cases for evidence of Hedgehog pathwa...

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Detalles Bibliográficos
Autores principales: Yap, Jason, Fox, Richard, Narsia, Natalie, Pinheiro-Maia, Sonia, Pounds, Rachel, Woodman, Ciaran, Luesley, David, Ganesan, Raji, Kehoe, Sean, Dawson, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209322/
https://www.ncbi.nlm.nih.gov/pubmed/30379908
http://dx.doi.org/10.1371/journal.pone.0206553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209322/
https://www.ncbi.nlm.nih.gov/pubmed/30379908
http://dx.doi.org/10.1371/journal.pone.0206553

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