Rare Stochastic Expression of O6-Methylguanine- DNA Methyltransferase (MGMT) in MGMT-Negative Melanoma Cells Determines Immediate Emergence of Drug-Resistant Populations upon Treatment with Temozolomide In Vitro and In Vivo

The chemotherapeutic agent temozolomide (TMZ) kills tumor cells preferentially via alkylation of the O6-position of guanine. However, cells that express the DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT), or harbor deficient DNA mismatch repair (MMR) function, are profoundly resista...

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Detalles Bibliográficos
Autores principales: Chen, Thomas C., Chan, Nymph, Minea, Radu O., Hartman, Hannah, Hofman, Florence M., Schönthal, Axel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209933/
https://www.ncbi.nlm.nih.gov/pubmed/30274152
http://dx.doi.org/10.3390/cancers10100362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209933/
https://www.ncbi.nlm.nih.gov/pubmed/30274152
http://dx.doi.org/10.3390/cancers10100362

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