Choline Kinase Alpha Inhibition by EB-3D Triggers Cellular Senescence, Reduces Tumor Growth and Metastatic Dissemination in Breast Cancer

Choline kinase (ChoK) is the first enzyme of the Kennedy pathway leading to the biosynthesis of phosphatidylcholine (PtdCho), the most abundant phospholipid in eukaryotic cell membranes. EB-3D is a novel choline kinase α1 (ChoKα1) inhibitor with potent antiproliferative activity against a panel of s...

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Detalles Bibliográficos
Autores principales: Mariotto, Elena, Viola, Giampietro, Ronca, Roberto, Persano, Luca, Aveic, Sanja, Bhujwalla, Zaver M., Mori, Noriko, Accordi, Benedetta, Serafin, Valentina, López-Cara, Luisa Carlota, Bortolozzi, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209942/
https://www.ncbi.nlm.nih.gov/pubmed/30360374
http://dx.doi.org/10.3390/cancers10100391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209942/
https://www.ncbi.nlm.nih.gov/pubmed/30360374
http://dx.doi.org/10.3390/cancers10100391

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