Preclinical evidence of the enhanced effectiveness of combined rapamycin and AICAR in reducing kidney cancer

Loss of Von Hippel‐Lindau in renal carcinoma cells results in upregulation of the activity of hypoxia‐inducible factor (HIF‐α), a major transcription factor involved in kidney cancer. Rapamycin as mammalian target of rapamycin inhibitor and 5‐aminoimidazole‐4‐carboxamide‐riboside (AICAR) as AMPK act...

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Detalles Bibliográficos
Autores principales: Liang, Sitai, Medina, Edward A., Li, Boajie, Habib, Samy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210038/
https://www.ncbi.nlm.nih.gov/pubmed/30107094
http://dx.doi.org/10.1002/1878-0261.12370

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210038/
https://www.ncbi.nlm.nih.gov/pubmed/30107094
http://dx.doi.org/10.1002/1878-0261.12370

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