Metformin blocks MYC protein synthesis in colorectal cancer via mTOR‐4EBP‐eIF4E and MNK1‐eIF4G‐eIF4E signaling

The antidiabetic drug metformin has been associated with reduced colorectal cancer (CRC) risk and improved prognosis of CRC patients. However, the detailed mechanisms underlying such beneficial effects remain unknown. In this study, we aimed to evaluate metformin activity in CRC models and unveil th...

Descripción completa

Detalles Bibliográficos
Autores principales: Shen, Peng, Reineke, Lucas C., Knutsen, Erik, Chen, Meng, Pichler, Martin, Ling, Hui, Calin, George A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210051/
https://www.ncbi.nlm.nih.gov/pubmed/30221473
http://dx.doi.org/10.1002/1878-0261.12384

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210051/
https://www.ncbi.nlm.nih.gov/pubmed/30221473
http://dx.doi.org/10.1002/1878-0261.12384

Ejemplares similares