Sensitization of Cancer Cells to Radiation and Topoisomerase I Inhibitor Camptothecin Using Inhibitors of PARP and Other Signaling Molecules

Radiation and certain anticancer drugs damage DNA, resulting in apoptosis induction in cancer cells. Currently, the major limitations on the efficacy of such therapies are development of resistance and adverse side effects. Sensitization is an important strategy for increasing therapeutic efficacy w...

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Autores principales: Matsuno, Yusuke, Hyodo, Mai, Fujimori, Haruka, Shimizu, Atsuhiro, Yoshioka, Ken-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210148/
https://www.ncbi.nlm.nih.gov/pubmed/30274183
http://dx.doi.org/10.3390/cancers10100364
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author Matsuno, Yusuke
Hyodo, Mai
Fujimori, Haruka
Shimizu, Atsuhiro
Yoshioka, Ken-ichi
author_facet Matsuno, Yusuke
Hyodo, Mai
Fujimori, Haruka
Shimizu, Atsuhiro
Yoshioka, Ken-ichi
author_sort Matsuno, Yusuke
collection PubMed
description Radiation and certain anticancer drugs damage DNA, resulting in apoptosis induction in cancer cells. Currently, the major limitations on the efficacy of such therapies are development of resistance and adverse side effects. Sensitization is an important strategy for increasing therapeutic efficacy while minimizing adverse effects. In this manuscript, we review possible sensitization strategies for radiation and anticancer drugs that cause DNA damage, focusing especially on modulation of damage repair pathways and the associated reactions.
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spelling pubmed-62101482018-11-02 Sensitization of Cancer Cells to Radiation and Topoisomerase I Inhibitor Camptothecin Using Inhibitors of PARP and Other Signaling Molecules Matsuno, Yusuke Hyodo, Mai Fujimori, Haruka Shimizu, Atsuhiro Yoshioka, Ken-ichi Cancers (Basel) Review Radiation and certain anticancer drugs damage DNA, resulting in apoptosis induction in cancer cells. Currently, the major limitations on the efficacy of such therapies are development of resistance and adverse side effects. Sensitization is an important strategy for increasing therapeutic efficacy while minimizing adverse effects. In this manuscript, we review possible sensitization strategies for radiation and anticancer drugs that cause DNA damage, focusing especially on modulation of damage repair pathways and the associated reactions. MDPI 2018-09-28 /pmc/articles/PMC6210148/ /pubmed/30274183 http://dx.doi.org/10.3390/cancers10100364 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Matsuno, Yusuke
Hyodo, Mai
Fujimori, Haruka
Shimizu, Atsuhiro
Yoshioka, Ken-ichi
Sensitization of Cancer Cells to Radiation and Topoisomerase I Inhibitor Camptothecin Using Inhibitors of PARP and Other Signaling Molecules
title Sensitization of Cancer Cells to Radiation and Topoisomerase I Inhibitor Camptothecin Using Inhibitors of PARP and Other Signaling Molecules
title_full Sensitization of Cancer Cells to Radiation and Topoisomerase I Inhibitor Camptothecin Using Inhibitors of PARP and Other Signaling Molecules
title_fullStr Sensitization of Cancer Cells to Radiation and Topoisomerase I Inhibitor Camptothecin Using Inhibitors of PARP and Other Signaling Molecules
title_full_unstemmed Sensitization of Cancer Cells to Radiation and Topoisomerase I Inhibitor Camptothecin Using Inhibitors of PARP and Other Signaling Molecules
title_short Sensitization of Cancer Cells to Radiation and Topoisomerase I Inhibitor Camptothecin Using Inhibitors of PARP and Other Signaling Molecules
title_sort sensitization of cancer cells to radiation and topoisomerase i inhibitor camptothecin using inhibitors of parp and other signaling molecules
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210148/
https://www.ncbi.nlm.nih.gov/pubmed/30274183
http://dx.doi.org/10.3390/cancers10100364
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