Two Missense Variants Detected in Breast Cancer Probands Preventing BRCA2-PALB2 Protein Interaction

PALB2 (partner and localizer of BRCA2) was initially identified as a binding partner of BRCA2. It interacts also with BRCA1 forming a complex promoting DNA repair by homologous recombination. Germline pathogenic variants in BRCA1, BRCA2 and PALB2 DNA repair genes are associated with high risk of dev...

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Detalles Bibliográficos
Autores principales: Caleca, Laura, Catucci, Irene, Figlioli, Gisella, De Cecco, Loris, Pesaran, Tina, Ward, Maggie, Volorio, Sara, Falanga, Anna, Marchetti, Marina, Iascone, Maria, Tondini, Carlo, Zambelli, Alberto, Azzollini, Jacopo, Manoukian, Siranoush, Radice, Paolo, Peterlongo, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210650/
https://www.ncbi.nlm.nih.gov/pubmed/30410870
http://dx.doi.org/10.3389/fonc.2018.00480

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210650/
https://www.ncbi.nlm.nih.gov/pubmed/30410870
http://dx.doi.org/10.3389/fonc.2018.00480

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