Novel fatty acyl apoE mimetic peptides have increased potency to reduce plasma cholesterol in mice and macaques

Ac-hE18A-NH(2) is a dual-domain apoE mimetic peptide that possesses the putative receptor binding domain from apoE (LRKLRKRLLR, denoted hE; residues 141–150) covalently attached to lipid-associating peptide 18A. Like apoE, Ac-hE18A-NH(2) reduces plasma cholesterol in animal models and exhibits anti-...

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Detalles Bibliográficos
Autores principales: Anantharamaiah, G. M., Garber, David W., Goldberg, Dennis, Morrel, Eric, Datta, Geeta, Palgunachari, Mayakonda N., Register, Thomas C., Appt, Susan E., White, C. Roger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210918/
https://www.ncbi.nlm.nih.gov/pubmed/30201630
http://dx.doi.org/10.1194/jlr.M085985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210918/
https://www.ncbi.nlm.nih.gov/pubmed/30201630
http://dx.doi.org/10.1194/jlr.M085985

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