Interplay of Klebsiella pneumoniae fabZ and lpxC Mutations Leads to LpxC Inhibitor-Dependent Growth Resulting from Loss of Membrane Homeostasis

Tight coordination of inner and outer membrane biosynthesis is very important in Gram-negative bacteria. Biosynthesis of the lipid A moiety of lipopolysaccharide, which comprises the outer leaflet of the outer membrane has garnered interest for Gram-negative antibacterial discovery. In particular, s...

Descripción completa

Detalles Bibliográficos
Autores principales: Mostafavi, Mina, Wang, Lisha, Xie, Lili, Takeoka, Kenneth T., Richie, Daryl L., Casey, Fergal, Ruzin, Alexey, Sawyer, William S., Rath, Christopher M., Wei, Jun-Rong, Dean, Charles R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211225/
https://www.ncbi.nlm.nih.gov/pubmed/30381354
http://dx.doi.org/10.1128/mSphere.00508-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211225/
https://www.ncbi.nlm.nih.gov/pubmed/30381354
http://dx.doi.org/10.1128/mSphere.00508-18

Ejemplares similares