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Interplay of Klebsiella pneumoniae fabZ and lpxC Mutations Leads to LpxC Inhibitor-Dependent Growth Resulting from Loss of Membrane Homeostasis

Tight coordination of inner and outer membrane biosynthesis is very important in Gram-negative bacteria. Biosynthesis of the lipid A moiety of lipopolysaccharide, which comprises the outer leaflet of the outer membrane has garnered interest for Gram-negative antibacterial discovery. In particular, s...

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Detalles Bibliográficos
Autores principales:	Mostafavi, Mina, Wang, Lisha, Xie, Lili, Takeoka, Kenneth T., Richie, Daryl L., Casey, Fergal, Ruzin, Alexey, Sawyer, William S., Rath, Christopher M., Wei, Jun-Rong, Dean, Charles R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211225/ https://www.ncbi.nlm.nih.gov/pubmed/30381354 http://dx.doi.org/10.1128/mSphere.00508-18

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