The small organic molecule C19 binds and strengthens the KRAS4b-PDEδ complex and inhibits growth of colorectal cancer cells in vitro and in vivo

BACKGROUND: Colorectal cancer is the third most common cancer worldwide; and in 40% of all cases, KRAS4b-activating mutations occur. KRAS4b is transported by phosphodiesterase-6δ (PDEδ) to the plasma membrane, where it gets activated. PDEδ downregulation prevents redistribution and activation of KRA...

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Detalles Bibliográficos
Autores principales: Cruz-Nova, Pedro, Schnoor, Michael, Correa-Basurto, José, Bello, Martiniano, Briseño-Diaz, Paola, Rojo-Domínguez, Arturo, Ortiz-Mendoza, Carlos M., Guerrero-Aguirre, Jorge, García-Vázquez, Francisco J., Hernández-Rivas, Rosaura, Thompson-Bonilla, María del Rocío, Vargas, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211466/
https://www.ncbi.nlm.nih.gov/pubmed/30382908
http://dx.doi.org/10.1186/s12885-018-4968-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211466/
https://www.ncbi.nlm.nih.gov/pubmed/30382908
http://dx.doi.org/10.1186/s12885-018-4968-3

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