The tumor suppressor BRCA1-BARD1 complex localizes to the synaptonemal complex and regulates recombination under meiotic dysfunction in Caenorhabditis elegans

Breast cancer susceptibility gene 1 (BRCA1) and binding partner BRCA1-associated RING domain protein 1 (BARD1) form an essential E3 ubiquitin ligase important for DNA damage repair and homologous recombination. The Caenorhabditis elegans orthologs, BRC-1 and BRD-1, also function in DNA damage repair...

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Detalles Bibliográficos
Autores principales: Li, Qianyan, Saito, Takamune T., Martinez-Garcia, Marina, Deshong, Alison J., Nadarajan, Saravanapriah, Lawrence, Katherine S., Checchi, Paula M., Colaiacovo, Monica P., Engebrecht, JoAnne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211623/
https://www.ncbi.nlm.nih.gov/pubmed/30383767
http://dx.doi.org/10.1371/journal.pgen.1007701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211623/
https://www.ncbi.nlm.nih.gov/pubmed/30383767
http://dx.doi.org/10.1371/journal.pgen.1007701

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