High-throughput characterization of genetic effects on DNA–protein binding and gene transcription

Many variants associated with complex traits are in noncoding regions and contribute to phenotypes by disrupting regulatory sequences. To characterize these variants, we developed a streamlined protocol for a high-throughput reporter assay, Biallelic Targeted STARR-seq (BiT-STARR-seq), that identifi...

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Detalles Bibliográficos
Autores principales: Kalita, Cynthia A., Brown, Christopher D., Freiman, Andrew, Isherwood, Jenna, Wen, Xiaoquan, Pique-Regi, Roger, Luca, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2018
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211638/
https://www.ncbi.nlm.nih.gov/pubmed/30254052
http://dx.doi.org/10.1101/gr.237354.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211638/
https://www.ncbi.nlm.nih.gov/pubmed/30254052
http://dx.doi.org/10.1101/gr.237354.118

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